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@zhoujj2013 2017-10-10T06:33:33.000000Z 字数 5315 阅读 382

那些年我们一起读过的paper(2017年1-6月)

phdnote


20170626--elincRNA, enhancer, super-enhancer, single cell histone

The Super-Enhancer-Derived alncRNA-EC7/Bloodlinc Potentiates Red Blood Cell Development in trans.
https://www.ncbi.nlm.nih.gov/pubmed/28636939

An atlas of human long non-coding RNAs with accurate 5′ ends
https://www.nature.com/nature/journal/v543/n7644/full/nature21374.html

Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells
http://www.nature.com/cr/journal/v27/n8/full/cr201782a.html

Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos.
https://www.ncbi.nlm.nih.gov/pubmed/27626379

20170601--CRISPR screening of functional elements

Unlinking an lncRNA from Its Associated cis Element.
https://www.ncbi.nlm.nih.gov/pubmed/27041223

Pooled CRISPR screening with single-cell transcriptome readout
http://www.nature.com/nmeth/journal/v14/n3/full/nmeth.4177.html

Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens
http://www.cell.com/cell/fulltext/S0092-8674(16)31610-5

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq
http://www.cell.com/cell/fulltext/S0092-8674(16)31611-7

A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response
http://www.cell.com/cell/fulltext/S0092-8674(16)31660-9

20170522--Enhancer activity, super-enhancer, Runx3

Multiplexed Engineering and Analysis of Combinatorial Enhancer Activity in Single Cells.
https://www.ncbi.nlm.nih.gov/pubmed/28416141

Glucocorticoid Receptor:MegaTrans Switching Mediates the Repression of an ERα-Regulated Transcriptional Program
https://www.ncbi.nlm.nih.gov/pubmed/28475868

Detecting Novel Associations in Large Data Sets
http://science.sciencemag.org/content/334/6062/1518

An ensemble of regulatory elements controls Runx3 spatiotemporal expression in subsets of dorsal root ganglia proprioceptive neurons
http://genesdev.cshlp.org/content/30/23/2607.full

20170518--lncRNAs, RNA structure

SLERT Regulates DDX21 Rings Associated with Pol I Transcription.
https://www.ncbi.nlm.nih.gov/pubmed/28475895

The identification and functional annotation of RNA structures conserved in vertebrates
http://genome.cshlp.org/content/27/8/1371.full

Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.
https://www.ncbi.nlm.nih.gov/pubmed/28396406

20170508--aging

Aging-Dependent Demethylation of Regulatory Elements Correlates with Chromatin State and Improved β Cell Function.
https://www.ncbi.nlm.nih.gov/pubmed/26321660

20170502--eRNA and mutation

Enhancers as non-coding RNA transcription units: recent insights and future perspectives.
https://www.ncbi.nlm.nih.gov/pubmed/26948815

20170418--variant annotation, enhancer

Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements
http://genesdev.cshlp.org/content/31/6/590.full

A CD47-associated super-enhancer links pro-inflammatory signalling to CD47 upregulation in breast cancer.
https://www.ncbi.nlm.nih.gov/pubmed/28378740

Fast, scalable prediction of deleterious noncoding variants from functional and population genomic data.
https://www.ncbi.nlm.nih.gov/pubmed/28288115

Potential energy landscapes identify the information-theoretic nature of the epigenome.
https://www.ncbi.nlm.nih.gov/pubmed/28346445

20170327--aging, metabolism

Impaired energy metabolism of senescent muscle satellite cells is
associated with oxidative modifications of glycolytic enzymes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5270674/

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide
http://www.nature.com/nature/journal/v541/n7636/full/nature21034.html

Pten is necessary for the quiescence and maintenance of adult muscle stem cells
https://www.nature.com/articles/ncomms14328?WT.feed_name=subjects_adult-stem-cells

20170306--lncRNA, enhancer, mutation

Transcription factor assisted loading and enhancer dynamics dictate the hepatic fasting response.
https://www.ncbi.nlm.nih.gov/pubmed/28031249

Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(16)30595-2

Local regulation of gene expression by lncRNA promoters, transcription and splicing
https://www.nature.com/nature/journal/v539/n7629/full/nature20149.html

Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD
https://www.nature.com/articles/ncomms14016

A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers
http://www.nature.com/ng/journal/v49/n3/full/ng.3771.html

Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes.
https://www.ncbi.nlm.nih.gov/pubmed/27895109

20170213--CBP, eRNA, single cell rnaseq, iPSC, TFs

Cooperative Binding of Transcription Factors Orchestrates Reprogramming.
https://www.ncbi.nlm.nih.gov/pubmed/28111071

Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq
http://www.cell.com/cell/fulltext/S0092-8674(16)31611-7

RNA Binding to CBP Stimulates Histone Acetylation and Transcription
http://www.cell.com/cell/fulltext/S0092-8674(16)31736-6

20170116--IHEC papers

Lineage-Specific Genome Architecture Links Enhancers and Non-coding Disease Variants to Target Gene Promoters
https://www.ncbi.nlm.nih.gov/pubmed/27863249

Nucleosome Density ChIP-Seq Identifies Distinct Chromatin Modification Signatures Associated with MNase Accessibility.
https://www.ncbi.nlm.nih.gov/pubmed/27851972

A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome.
https://www.ncbi.nlm.nih.gov/pubmed/27851967

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